Anti-SLC1A2 (EAAT2) (Human) pAb

Product Code: MBL-BMP069

Supplier: MBL

Code	Size	Price

MBL-BMP069

100 ul

£323.00

Quantity:

Prices exclude any Taxes / VAT

Overview

Host Type: Rabbit

Antibody Isotype: IgG

Antibody Clonality: Polyclonal

Regulatory Status: RUO

Target Species: Human

Applications:

Flow Cytometry
Immunocytochemistry (ICC)
Immunohistochemistry (IHC)

Shipping:

4°C

Storage:

-20°C

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Documents

Datasheet

Further Information

Applications:

FCM - 1:500 ICC - 1:500 IHC - 1:2500 (Heat treatment required for paraffin)

Background:

Members of the solute carrier family 1 are classified as high-affinity glutamate and neutral amino acid transporters. These are also referred to as excitatory amino acid transporters, which regulate glutamatergic signal transmission by clearing excess glutamate after synaptic release in the central nervous system. SLC1A2/EAAT2 is predominantly located on the astroglia in the brain and is believed to act as a glial-specific glutamate transporter. Lethal seizures and increased susceptibility to acute cortical injury have been observed in mice with disrupted slc1a2 gene. In humans, a severe decrease in the expression levels of SLC1A2/EAAT2 is noted in the brain of patients with amyotrophic lateral sclerosis.

Formulation:

100 ul volume of PBS containing 50% glycerol, pH 7.2. No preservative is contained.

Gene IDs:

Human: 6506 Mouse: 20511

Immunogen Translated:

Synthetic peptide derived from human SLC1A2

Reactivity:

This antibody can be used to stain endogenous antigen in paraffin embedded human tissues including the cerebrum by Immunohistochemistry. The reactivity has been confirmed by Immunocytochemistry and intracellular Flow cytometry to detect the full length of human SLC1A2 transiently expressed in HEK 293T cells.

Shelf Life:

1 year

Source:

This antibody was affinity purified from rabbit serum. The rabbit was immunized with a synthetic peptide derived from human SLC1A2.

Target:

SLC1A2/EAAT2

References

1) Mallolas, J., et al., J. Exp. Med. 203, 711-717 (2006) 2) Su, Z., et al., PNAS 100, 1955-1960 (2003) 3) Trotti, D., et al., J. Biol. Chem. 276, 576-582 (2001) 4) Tanaka, K., et al., Science 276, 1699-1702 (1997) 5) Shashidharan, P., et al., Biochim. Biophys. Acta. 1191, 393-396 (1994) 6) Rothstein, J. D., et al., Neuron 13, 713-725 (1994) 7) Krishnan, S. N., et al., Soc. Neurosci. Abstr. 19, 219 (1993)