Anti-SynCAM (TSLC1/CADM1) (Human) mAb

Product Code: MBL-CM004-3

Supplier: MBL

Code	Size	Price

MBL-CM004-3

100 ug

£404.00

Quantity:

Prices exclude any Taxes / VAT

Overview

Host Type: Chicken

Antibody Isotype: IgY

Antibody Clonality: Monoclonal

Regulatory Status: RUO

Target Species:

Human
Mouse

Applications:

Flow Cytometry
Immunocytochemistry (ICC)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)

Shipping:

4°C

Storage:

-20°C

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Documents

Datasheet

Further Information

Applications:

WB - 1 ug/mL (chemiluminescence detection system) IP - 10 ug/200 uL of cell extract from 5x106 cells IHC - 10 ug/mL (Heat treatment required for paraffin) ELISA - 1 ug/mL (final concentration)

Background:

SynCAM (Synaptic Cell Adhesion Molecule), also known as TSLC1 (tumor suppressor in lung cancer-1), SgIGSF, or CADM1, is a homophilic, transmembrane Ig-domain containing protein with intracellular PDZ protein-binding motifs. Although originally identified as a tumor suppressor of small lung cell carcinomas, SynCAM appears to be primarily involved in intracellular adhesion and synapse formation. The majority of SynCAM is localized to synaptic sites where it initiates synaptic assembly and synapse differentiation throughout the central nervous system. SynCAM also mediates the cellular adhesion of spermatogenic cells to Sertoli cells and mast cells to fibroblasts.

Concentration:

1 mg/mL

Formulation:

100 ug IgG in 100 ul volume of PBS containing 50% glycerol, pH 7.2. No preservative is contained.

Gene IDs:

Human: 23705 Mouse: 54725

Immunogen Translated:

Recombinant fusion protein Fc-SynCAM

Reactivity:

This antibody reacts with extracellular domain of SynCAM on Flow cytometry, Western blotting, Immunoprecipitation and Immunohistochemistry.

Shelf Life:

1 year

Source:

This antibody was purified from hybridoma (clone 3E1) supernatant using anti-IgY affinity column. This hybridoma was established by fusion of chicken B cell line MUH1 cell with chicken splenocyte immunized with recombinant Fc fusion SynCAM.

Target:

SynCAM (TSLC1/CADM1)

References

1) Hagiyama, M., et al., Am. J. Pathol. 174, 2278-2289 (2009) 2) Hasstedt, S. J., et al., Blood 114, 3084-3091 (2009) 3) Hollins, F., et al., J. Immunol. 181, 2772-2780 (2008) 4) Wakayama, T., et al., Biol. Reprod. 76, 1081-1090 (2007) 5) Fogel, A. I., et al., J. Neurosci. 27, 12516-12530 (2007) 6) Yang, W., et al., J. Immunol. 176, 1238-1243 (2006) 7) Furuno, T., et al., J. Immunol. 174, 6934-6942 (2005) 8) Sara, Y., et al., J. Neuroscience 25, 260-270 (2005) 9) Biederer, T., et al., Science 297, 1525-1531 (2002) Clone 3E1 is used in the reference number 1)-6).