Anti-SynCAM (TSLC1/CADM1) (Human) pAb
| Code | Size | Price |
|---|
| MBL-CM005-3 | 100 ug | £404.00 |
Quantity:
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Overview
Host Type: Chicken
Antibody Isotype: IgY
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Application: Flow Cytometry
Shipping:
4°C
Storage:
-20°C
Documents
Further Information
Applications:
FCM - 1 ug/mL (final concentration) Other - It is reported that this monoclonal antibody can be used in adhesion blocking experiments in the reference number 2) and 3).
Background:
SynCAM (Synaptic Cell Adhesion Molecule), also known as TSLC1 (tumor suppressor in lung cancer-1), SgIGSF, or CADM1, is a homophilic, transmembrane Ig-domain containing protein with intracellular PDZ protein-binding motifs. Although originally identified as a tumor suppressor of small lung cell carcinomas, SynCAM appears to be primarily involved in intracellular adhesion and synapse formation. The majority of SynCAM is localized to synaptic sites where it initiates synaptic assembly and synapse differentiation throughout the central nervous system. SynCAM also mediates the cellular adhesion of spermatogenic cells to Sertoli cells and mast cells to fibroblasts.
Concentration:
1 mg/mL
Formulation:
1 mg/mL in PBS/50% glycerol, pH 7.2
Gene IDs:
Human: 23705 Mouse: 54725
Immunogen Translated:
Recombinant fusion protein SynCAM / Fc
Reactivity:
This antibody reacts with extracellular domain of SynCAM on Flow cytometry.
Shelf Life:
1 year
Target:
SynCAM/TSLC1
References
1)
Hollins, F., et al., J. Immunol. 181, 2772-2780 (2008)
2)
Yang, W., et al., J. Immunol. 176, 1238-1243 (2006)
3)
Furuno, T., et al., J. Immunol. 174, 6934-6942 (2005)
4)
Sara, Y., et al., J. Neuroscience 25, 260-270 (2005)
5)
Biederer, T., et al., Science 297, 1525-1531 (2002)
Clone 9D2 is used in the reference number 1) - 3).