cGK Positive Control (Full length)
| Code | Size | Price |
|---|
| MBL-CY-E1161-2 | 200 Assays | £318.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
Dry Ice
Storage:
-70°C
Documents
Further Information
Applications:
Other - 20 units/well
Background:
Cyclic GMP-dependent protein kinases (protein kinase G, PKG, cGK) are the major receptors of intracellular cGMP. These serine/threonine kinases mediate a plethora of physiological responses. Members of this family include cGKIα, cGKIβ, and cGKII, and each member contains a leucine zIPer motif at the N-terminus. cGKI is thought to control the contractility of vascular muscle, the permeability of endothelial cells, and to inhibit platelet aggregation. It phosphorylates and thereby inhibits nitric oxide synthase. cGKII plays a key role in the regulation of the intestinal ion transport system, as well as inhibiting renin secretion in kidneys. Deregulation of cGMP kinase family members could be a factor in various human diseases.
Formulation:
Supplied in 20mM HEPES-KOH (pH 7.5), 1mM EDTA, 1mM DTT, 50mM NaCl, 0.03 % Brij35 and 50% glycerol.
Gene IDs:
Human: 5592 Mouse: 19091
MW:
Recombinant cGMP-Dependent Protein Kinase demonstrates
a single 75 kDa band by SDS-PAGE analysis.
Purity:
>90% pure as determined by SDS-PAGE analysis.
Shelf Life:
1 year
Target:
cGK
References
1. Edelman, A.M., et al. Ann. Rev. Biochem. 56, 567, 1987.
2. Beebe, S.J. and Corbin, J.D. In: The Enzymes, Vol. 17, 3rd
ed., Boyer, P.D. and Krebs, E.D., eds., 44, 1986.
3. Corbin, J.D. and Doskeland, S.O. et al. J. Biol. Chem. 258,
11391, 1983.
4. Endo, S et al. Proc. Natl. Acad. Sci. USA. 96, 2467-2472,
1999.