CircuLex PCSK9 D374Y in culture medium
Code | Size | Price |
---|
MBL-CY-R2311 | 50 ug | £382.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
Dry Ice
Storage:
-70°C
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Further Information
Background:
PCSK9 binds to the LDL receptor in vitro and in vitro. Human PCSK9 D374Y
containing a C-terminal His-tag, expressed in HEK 293 cells. Binding capability to EGF-AB domain of
LDL receptor was confirmed by using CircuLex PCSK9-LDLR in vitro Binding Assay Kit (CY-8150).
The PCSK9 D374Y in culture medium might be used for LDLR degradation assay on HepG2 cell.
Concentration:
25 ug/mL
Formulation:
The PCSK9 D374Y in culture medium is supplied frozen in DME, 10% FCS and
appropriate antibiotics in sterile condition.
Gene IDs:
Human: 255738 Mouse: 100102
MW:
The PCSK9 D374Y in culture medium demonstrates 62 kDa (catalytic and
C-terminal domain) and 16 kDa (prodomain band) by Western blot analysis.
Shelf Life:
1 year
Source:
Full length human PCSK9 having one mutation D374Y, containing C-terminal His-tag,
expressed in HEK 293 cells.
Target:
PCSK9
References
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Wickham L, Erlich D, et al. (2003) Nat Genet 34:154?156.
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Fredenrich A, et al. (2005) Hum Mutat 26:497.
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Ho, Y. K., Hammer, R. E., and Horton, J. D. (2006) J. Clin. Investig. 116, 2995?3005 10. Cameron, J., Holla, O. L., Ranheim, T., Kulseth, M. A., Berge, K. E., and Leren, T. P. (2006) Hum.
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Deisenhofer (2008) ) Proc Natl Acad Sci USA 105: 1820?1825.