CircuLex PCSK9 Wild Type
Code | Size | Price |
---|
MBL-CY-R2330 | 50 ug | £578.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
Dry Ice
Storage:
-70°C
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Further Information
Background:
PCSK9 binds to the LDL receptor in vitro and in vitro. Human PCSK9 wild type containing a C-terminal His-tag, expressed in HEK 293 cells. Binding capability to EGF-AB domain of LDL receptor was confirmed by using CircuLex PCSK9-LDLR in vitro Binding Assay Kit (CY-8150).
Concentration:
500 ug/mL
Formulation:
The PCSK9 Wild Type is supplied frozen in PBS pH 7.2, 10 % glycerol.
Gene IDs:
Human: 255738 Mouse: 100102
MW:
The PCSK9 Wild Type demonstrates 62 kDa (catalytic and C-terminal domain) and 16 kDa (prodomain band) by SDS-PAGE analysis.
Purification:
Purified by Ni-chelating chromatography
Purity:
The PCSK9 Wild Type is greater than 95 % pure as determined by SDS-PAGE analysis.
Shelf Life:
1 year
Source:
Full length human PCSK9 wild type, containing C-terminal His-tag, expressed in HEK 293 cells.
Target:
PCSK9
References
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2. Abifadel M, Varret M, Rabes JP, Allard D, Ouguerram K, Devillers M, Cruaud C, Benjannet S, Wickham L, Erlich D, et al. (2003) Nat Genet 34:154?156.
3. Leren TP (2004) Clin Genet 65:419?422.
4. Allard D, Amsellem S, Abifadel M, Trillard M, Devillers M, Luc G, Krempf M, Reznik Y, Girardet JP, Fredenrich A, et al. (2005) Hum Mutat 26:497.
5. Cohen JC, Boerwinkle E, Mosley TH, Jr, Hobbs HH (2006) N Engl J Med 354, 1264?1272.
6. Berge KE, Ose L, Leren TP (2006) Arterioscler Thromb Vasc Biol 26:1094?1100.
7. Maxwell KN, Breslow JL (2004) Proc Natl Acad Sci USA 101:7100?7105.
8. Rashid S, Curtis DE, Garuti R, Anderson NN, Bashmakov Y, Ho YK, Hammer RE, Moon YA, Horton JD (2005) Proc Natl Acad Sci USA 102:5374?5379.
9. Lagace, T. A., Curtis, D. E., Garuti, R., McNutt, M. C., Park, S. W., Prather, H. B., Anderson, N. N., Ho, Y. K., Hammer, R. E., and Horton, J. D. (2006) J. Clin. Investig. 116, 2995?3005
10. Cameron, J., Holla, O. L., Ranheim, T., Kulseth, M. A., Berge, K. E., and Leren, T. P. (2006) Hum. Mol. Genet. 15, 1551?1558
11. Zhang, D. W., Lagace, T. A., Garuti, R., Zhao, Z., McDonald, M., Horton, J. D., Cohen, J. C., and Hobbs, H. H. (2007) J. Biol. Chem. 282, 18602?18612
12. Hyock Joo Kwon*, Thomas A. Lagace?, Markey C. McNutt?, Jay D. Horton??, and Johann Deisenhofer (2008) ) Proc Natl Acad Sci USA 105: 1820?1825.