CircuLex PCSK9 D374Y (His-tagged)
| Code | Size | Price |
|---|
| MBL-CY-R2331 | 10 ug | £637.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Regulatory Status: RUO
Shipping:
Dry Ice
Storage:
-70°C
Documents
Further Information
Background:
PCSK9 binds to the LDL receptor in vitro and in vitro. Human PCSK9 D374Y containing a C-terminal His-tag, expressed in HEK 293 cells. Binding capability to EGF-AB domain of LDL receptor was confirmed by using CircuLex PCSK9-LDLR in vitro Binding Assay Kit (CY-8150).
Concentration:
100 ug/mL
Formulation:
The PCSK9 D374Y is supplied frozen in PBS pH 7.2, 10 % glycerol.
Gene IDs:
Human: 255738 Mouse: 100102
MW:
The PCSK9 D374Y demonstrates 64 kDa (catalytic and C-terminal domain) and 16 kDa (prodomain band) by SDS-PAGE analysis.
Purification:
Purified by Ni-chelating chromatography
Purity:
The PCSK9 D374Y is greater than 95 % pure as determined by SDS-PAGE analysis.
Shelf Life:
1 year
Source:
Full length human PCSK9 having one mutation D374Y, containing C-terminal His-tag, expressed in HEK 293 cells.
Target:
PCSK9
References
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12. Hyock Joo Kwon*, Thomas A. Lagace?, Markey C. McNutt?, Jay D. Horton??, and Johann Deisenhofer (2008) ) Proc Natl Acad Sci USA 105: 1820?1825.