CircuLex PCSK9 R194A (Human)
| Code | Size | Price |
|---|
| MBL-CY-R2333 | 20 ug | £578.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Human
Regulatory Status: RUO
Shipping:
Dry Ice
Storage:
-70°C
Documents
Further Information
Background:
PCSK9 binds to the LDL receptor in vitro and in vitro. Human PCSK9 R194A
containing a C-terminal His-tag, expressed in HEK 293 cells. Reduction of binding activity to EGF-AB
domain of LDL receptor, compared to wild type PCSK9, was confirmed by using CircuLex
PCSK9-LDLR in vitro Binding Assay Kit (Cat# CY-8150).
Concentration:
100 ug/mL
Formulation:
The PCSK9 R194A is supplied frozen in PBS pH 7.2, 10 % glycerol.
Gene IDs:
Human: 255738 Mouse: 100102
MW:
The PCSK9 R194A demonstrates 64 kDa (catalytic and C-terminal domain) and 16
kDa (prodomain) by SDS-PAGE analysis.
Purification:
Purified by Ni-chelating chromatography
Purity:
The PCSK9 R194A is greater than 95 % pure as determined by SDS-PAGE analysis.
Shelf Life:
1 year
Source:
Full length human PCSK9 having one mutation R194A, containing C-terminal His-tag,
expressed in HEK 293 cells.
Target:
PCSK9
References
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Fredenrich A, et al. (2005) Hum Mutat 26:497.
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(2008) ) Proc Natl Acad Sci USA 105: 1820?1825.
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