Anti-RCAS1 (Human) mAb

RCAS1 (receptor-binding cancer antigen expressed on SiSo cells) is a novel tumor-associated antigen expressed in human uterine and ovarian carcinomas. The predicted amino acid sequence of RCAS1 (213 aa) possesses an N-terminal transmembrane region and a coiled-coil structure in the C-terminal portion, indicating that RCAS1 is a type II membrane protein able to form oligomers through the coiled-coil structure. RCAS1 revealed different expression pattern from the known tumor associated antigens such as, YH206, GA733, CA125, CEA and sialyl Lewis molecules in human tumor cell lines. Recent study indicated RCAS1 acts as a ligand for a putative receptor present on various human cells including T, B and NK cells. RCAS1 inhibited the in vitro growth of receptor-expressing cells and induced apoptosis. It was suggested that tumor cells might evade immune surveillance by expression of RCAS1.

6 mL of prediluted antibody from the supernatant with preservative (0.09% NaN3).*Azide may react with copper or lead in plumbing system to form explosive metal azides. Therefore, always flush plenty of water when disposing materials containing azide into

Human: 9166 Mouse: 55960

Jugular gland of human uterine cancer cells

This antibody reacts with RCAS1 on Immunocytochemistry.

3 years

This product is culture supernatant. This hybridoma (clone 22-1-1) was established by fusion of mouse myeloma cell x63.Ag8.653 with Balb/c mouse splenocyte immunized with human uterine cervical adenocarcinoma cells.

RCAS1