Anti-CD112 (Nectin-2) (Mouse) mAb
| Code | Size | Price |
|---|
| MBL-D083-3 | 100 ug | £327.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rat
Antibody Isotype: IgG2a κ
Antibody Clonality: Monoclonal
Antibody Clone: 502-57
Regulatory Status: RUO
Target Species: Mouse
Application: Immunocytochemistry (ICC)
Shipping:
4°C
Storage:
-20°C
Documents
Further Information
Applications:
ICC - 5-10 ug/mL
Background:
Nectins are Ca2+-independent
immunoglobulin-like cell-cell-adhesion molecules. Nectins
comprise a family of four members: nectin-1
(CD111/PRR-1), nectin-2 (CD112/PRR-2), nectin-3
(CD113/PRR-3), and nectin-4. Nectin-2 and -3 are
ubiquitously expressed whereas nectin-1 is abundantly
expressed in brain. Nectin-2 is a ligands for CD226
(DNAM-1) which is an adhesion molecule involved in NK
and T cell-mediated cytotoxicity against certain tumors.
Concentration:
1 mg/ml
Formulation:
100 ug IgG in a 100 ul volume of PBS containing 50% glycerol, pH 7.2. Contains nopreservatives.
Gene IDs:
Human: 5819 Mouse: 19294
Immunogen Translated:
Mouse recombinant extracellular domain fusion protein value Kuching 2 (1-338a.a.)-Fc
Reactivity:
This antibody reacts with mouse CD112
antigen on Immunocytochemistry.
Shelf Life:
1 year
Source:
This antibody was purified from hybridoma
(clone 502-57) supernatant using protein G agarose. This
hybridoma was established by fusion of mouse myeloma
cell P3U1 with Wister Rat B-lymphocyte immunized with
the recombinant mouse Nectin-2 extra cellular region-Fc
fusion protein (1-338 aa.).
Target:
Nectin 2
References
1) Inagaki, M., et al., Genes Cells 11, 1125-1132 (2006)
2) Inagaki, M., et al., Development 132, 1525-1537 (2005)
3) Guttman, J. A., et al., Biol. Reprod 71, 548-559 (2004)
4) Mizoguchi, A., et al., J. Cell Biol. 156, 555-565(2002)
5) Miyashita, M., et al., J. Biol. Chem. 275, 613-618 (2000)
6) Horikawa, S. K., et al., J. Biol. Chem. 275, 10291-10299 (2000)
7) Takahashi, K., et al., J. Cell Biol. 145, 539-549 (1999)
Clone 502-57 is used in these references.