Anti-CTLA-4 (CD152) mAb

FCM - 10-20 ug/mL

?The coreceptor cytotoxic T lymphocyte?associated antigen 4 (CTLA-4/CD152) is a member of the immunoglobulin superfamily, expressed on activated T lymphocytes 2-3 days after stimulation via the T cell receptor, regulate the threshold of signals during T cell activation, but the mechanism is still not clear. Like CD28, CTLA-4 shares the same ligands, namely CD80 (B7-1) and CD86 (B7-2), but CTLA-4 binds with an affinity 10- to 20-fold higher than that of CD28. Mutation of CTLA-4 gene has been related to autoimmune diseases such as insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus.

100 ug IgG in 100 ul volume of PBS containing 50% glycerol, pH 7.2. No preservative iscontained.

Human: 1493 Mouse: 12477

Human recombinant full-length CTLA-4

This antibody r eacts with human CTLA-4 on Flow cytometry.

1 year

This antibody was purified from hybridoma (clone MIH8) supernatant using protein A agarose. This hybridoma was established by fusion of mouse myeloma cell SP2/0 with DBA/2 mouse splenocyte immunized with full-length human CTLA-4 transfected p815 cells.

CD152