Anti-IFN-gamma (Human) mAb

NT - 3.95x103 (NU/mL) The apparent neutralizing effect of antibody against IFN-? may vary depending on cell types and growth conditions. The amounts of neutralized IFN-? activity by the serially diluted antibodies were measured under the condition stated in the following APPLICATION. The diluted antibody at the dilution factor 3.95 x 103 may neutralize the 1 IU/mL (International Reference Unit) of IFN-? in the solution, that is, 1 NU/mL (arbitrary standardized neutralizing unit) of antibody may neutralize the 1 IU/mL of IFN-? activity in the solution.

IFN-?, also known as type II interferon, is mainly produced in activated T lymphocytes and NK cells. It is involved in the regulation of nearly all phases of immune and inflammatory responses, such as the activation, growth, and differentiation of T cells, B cells, macrophages and also several other cell types, including endothelial cells and fibroblasts. IFN-? has antiviral and antiproliferative activities, it has also been shown to inhibit the proliferation of a variety of cells. Synthesis of IFN-? is upregulated by IL2, FGF basic and EGF.

1 mg/mL

100 ug IgG in 100 ul volume of PBS containing 50% glycerol, pH 7.2. No preservative iscontained.

Human: 3458 Mouse: 15978

Purified human IFN-γ

This antibody neutralizes human IFN-?

1 year

This antibody was purified from hybridoma (clone #6) supernatant using protein A agarose. This hybridoma was established by fusion of mouse myeloma cell SP2/0 with Balb/c mouse splenocyte immunized with purified human IFN-?.