Anti-Phospho-STAT3 (Tyr708) (Zebrafish) mAb

WB - 1 ug/mL (chemiluminescence detection system)

STAT (Signal Transducers and Activators of Transcription) proteins play important roles in development, cell differentiation, and cell cycle control. STAT3 is an ~85 kDa protein involved in the signaling pathways of many cytokines and growth factors, including GCSF and IL-6, where it functions as a negative regulator of transcription. STAT3 is also constitutively activated in a number of human tumors and it possesses anti-apoptotic activity and oncogenic potential. STAT3 may also regulate apoptosis by inhibiting NFκB. Activation of STAT3 by tyrosine phosphorylation results in dimerization, nuclear translocation, and DNA binding.

1 mg/mL

100 ug IgG in 100 ul volume of PBS containing 50% glycerol, pH 7.2. No preservative iscontained.

Human: 6774 Mouse: 20848

12 peptides containing the phosphorylated Tyr708 of zebrafish STAT3 (CVTQPpYLKTKFI) (703-714 aa)

This antibody reacts with human and mouse STAT3 phosphorylated at Tyr705, and zebrafish STAT3 phosphorylated at Tyr708.

1 year

This antibody was purified from hybridoma (clone PS3/1) supernatant using protein-A Sepharose. This hybridoma was established by fusion of mouse myeloma cell SP2/0 with Balb/c mouse splenocyte immunized with the 12 amino acids peptide CVTQPpYLKTKFI (a.a. 703~714) which contained the phosphorylated Tyr708 of zebrafish STAT3 (equivalent to Tyr705 in human and mouse.

STAT3