Anti-CD279 (PD-1) (Human) mAb

WB - 1ug/mL FCM - 10-20 ug/mL (final concentration)

?Human PD-1 (programmed death-1)is a 55 KDa member of the immunoglobulin superfamily that is induced in cells undergoing apoptosis. The PD-1 protein contains an immunoreceptor tyrosine-based inhibitory motif and is expressed predominantly on activated T and B lymphocytes. PD-1 plays a key role in peripheral tolerance and autoimmune disease and is thought to be involved in the maintenance of peripheral self-tolerance by serving as a negative regulator of immune responses. Two novel members of the B7 family have been identified as PD-1 ligands, PD-L1 (B7-H1) and PD-L2 (B7-DC). Evidence reported to date suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and up-regulation on activated antigen-presenting cells.

1 mg/mL

1.0 mg/mL in PBS/50% glycerol, pH 7.2

Human: 9825 Mouse: 263876

Fusion protein of human PD-1-Fc

This antibody reacts with human PD-1.

1 year

This antibody was purified from hybridoma (clone J110) supernatant using protein-A Sepharose. This hybridoma was established by fusion of mouse myeloma cell P3U1 with Balb/c mouse splenocyte immunized with the human PD-1-Fc fusion protein.

PD-1