Anti-CD279 (PD-1) (Human) mAb-FITC

FCM - 10 ug/mL (final concentration)

?Human PD-1 (programmed death-1) is a 55 kDa member of the immunoglobulin superfamily that is induced in cells undergoing apoptosis. The PD-1 protein contains an immunoreceptor tyrosine-based inhibitory motif (ITIM) and is expressed predominantly on activated T and B lymphocytes. PD-1 plays a key role in autoimmune disease and is thought to be involved in the maintenance of peripheral self-tolerance by serving as a negative regulator of immune responses. Two novel members of the B7 family have been identified as PD-1 ligands, PD-L1 (B7-H1) and PD-L2 (B7-DC). Evidence reported to date suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and up-regulation on activated antigen-presenting cells.

0.5 mg/mL

FITC

50 ug IgG in 100 ul volume of PBS containing 1% BSA and 0.09% NaN3.*Azide may react with copper or lead in plumbing systems to form explosive metal azides. Therefore, always flush drains thoroughly with plenty of water when disposing of materials contain

Human: 9825 Mouse: 263876

Human recombinant PD-1

This antibody reacts with human CD279/PD-1.

1 year

This antibody was purified from hybridoma (clone J110) supernatant using protein A agarose beads. This hybridoma was established by fusion of mouse myeloma cell P3U1 with Balb/c mouse splenocyte immunized with a human recombinant CD279/PD-1.

PD-1