Anti-CD279 (PD-1) (Human) mAb-PE
Code | Size | Price |
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MBL-D132-5 | 50 Tests | £301.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: IgG1
Antibody Clonality: Monoclonal
Antibody Clone: J110
Regulatory Status: RUO
Target Species: Human
Application: Flow Cytometry
Shipping:
4°C
Storage:
4°C
Documents
Further Information
Applications:
FCM - 20 uL (ready for use)
Background:
?Human PD-1 (programmed death-1) is a 55 kDa member of the immunoglobulin superfamily that is induced in cells undergoing apoptosis. The PD-1 protein contains an immunoreceptor tyrosine-based inhibitory motif (ITIM) and is expressed predominantly on activated T and B lymphocytes. PD-1 plays a key role in autoimmune disease and is thought to be involved in the maintenance of peripheral self-tolerance by serving as a negative regulator of immune responses. Two novel members of the B7 family have been identified as PD-1 ligands, PD-L1 (B7-H1) and PD-L2 (B7-DC). Evidence reported to date suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and up-regulation on activated antigen-presenting cells.
Conjugate:
PE
Formulation:
50 tests in 1 mL volume of PBS containing 1% BSA and 0.09% NaN3.*Azide may react with copper or lead in plumbing system to form explosive metal azides. Therefore, always flush plenty of water when disposing materials containing azide into drain.
Gene IDs:
Human: 9825 Mouse: 263876
Immunogen Translated:
Fusion protein of human PD-1-Fc
Reactivity:
This antibody reacts with human PD-1
on Flow cytometry.
Shelf Life:
1 year
Source:
This antibody was purified from hybridoma
(clone J110) supernatant using protein A agarose. This
hybridoma was established by fusion of mouse myeloma
cells P3U1 with Balb/c mouse splenocytes that were
immunized with a fusion protein of the extracellular
domain of human PD-1 and the constant region of human
γ1 heavy chain.
Target:
PD-1
References
1) Bennett, F., et al., J. Immunol. 170, 711-718 (2003)
2) Iwai, Y., et al., Immunol Lett. 83, 215-220 (2002)
Clone J110 is used in this reference.