Anti-CD279 (PD-1) (Human) mAb-PE
Code | Size | Price |
---|
MBL-D133-5 | 50 Tests | £301.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: IgG1
Antibody Clonality: Monoclonal
Antibody Clone: J105
Regulatory Status: RUO
Target Species: Human
Application: Flow Cytometry
Shipping:
4°C
Storage:
4°C
Documents
Further Information
Applications:
FCM - 20 uL (ready for use)
Background:
?Human PD-1 (programmed death-1) is a 55 kDa member of the immunoglobulin superfamily that is induced in cells undergoing apoptosis. The PD-1 protein contains an immunoreceptor tyrosine-based inhibitory motif (ITIM) and is expressed predominantly on activated T and B lymphocytes. PD-1 plays a key role in autoimmune disease and is thought to be involved in the maintenance of peripheral self-tolerance by serving as a negative regulator of immune responses. Two novel members of the B7 family have been identified as PD-1 ligands, PD-L1 (B7-H1) and PD-L2 (B7-DC). Evidence reported to date suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and up-regulation on activated antigen-presenting cells.
Conjugate:
PE
Formulation:
50 tests in 1 mL volume of PBS containing 1% BSA and 0.09% NaN3.* Azide may react with copper or lead in plumbing systems to form explosive metal azides. Therefore, always flush drains thoroughly with plenty of water when disposing of materials containin
Gene IDs:
Human: 9825 Mouse: 263876
Immunogen Translated:
Extracellular domain of human PD-1
Reactivity:
This antibody reacts with human PD-1
on Flow cytometry.
Shelf Life:
1 year
Source:
This antibody was purified from hybridoma
(clone J105) supernatant using protein A agarose. This
hybridoma was established by fusion of mouse myeloma
cell P3U1 with Balb/c mouse splenocyte that was
immunized with a fusion protein of the extracellular
domain of human PD-1 and the constant region of human
γ1 heavy chain.
Target:
PD-1
References
1) Kanai, T., et al., J. Immunol. 171, 4156-4163 (2003)
2) Iwai, Y., et al., Immunol Lett. 83, 215-220 (2002)
Clone J105 is used in this reference number 2).