Anti-CD112 (Human) mAb
| Code | Size | Price |
|---|
| MBL-D175-3 | 100 ug | £248.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rat
Antibody Isotype: IgG2a
Antibody Clonality: Monoclonal
Antibody Clone: TX31
Regulatory Status: RUO
Target Species: Human
Application: Flow Cytometry
Shipping:
4°C
Storage:
-20°C
Documents
Further Information
Applications:
FCM - 5-10 ug/mL (final concentration)
Background:
CD112, also known as Poliovirus
Receptor Related 2 (PRR2), is a transmembrane
glycoprotein that functions as the receptor for alpha-herpes
virus and pseudorabies virus entry into the cell. CD112 has
been shown to be identical to Nectin-2, an adhesion protein
localized to adherens junctions. CD112 is widely
expressed in neuronal, endothelial, and in particular,
epithelial cells, where it is found at the intercellular
junctions of adjacent cells. Additionally CD112 is detected
on hematopoietic progenitors expressing CD34, where it
plays a role in the regulation of hematopoietic/endothelial
cell interactions. At least two isoforms of CD112 mRNA
have been identified.
Concentration:
1 mg/mL
Formulation:
100 ug IgG in 100 ul volume of PBS containing 50% glycerol, pH 7.2. No preservative iscontained.
Gene IDs:
Human: 5819 Mouse: 19294
Immunogen Translated:
Recombinant human CD112
Reactivity:
This antibody reacts with human
CD112 antigen on Flow cytometry.
Shelf Life:
1 year
Source:
This antibody was purified from hybridoma
(clone TX31) supernatant using protein G agarose. This
hybridoma was established by fusion of mouse myeloma
cell Sp2/0 with Wister rat lymphocyte immunized with the
recombinant human CD112.
Target:
CD112
References
1) Tahara-Hanaoka, S., et al., Blood 107, 1491-1496 (2006)
2) Tahara-Hanaoka, S., et al., Int. Immunol. 16, 533-538 (2004)
3) Bottino, C., et al., J. Exp. Med. 198, 557-567 (2003)
Clone TX31 is used in reference number 1) and 2).