Anti-Granulysin (Human) mAb
| Code | Size | Price |
|---|
| MBL-D185-3 | 100 ug | £328.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: IgG1
Antibody Clonality: Monoclonal
Antibody Clone: RC8
Regulatory Status: RUO
Target Species: Human
Applications:
- Flow Cytometry
- Immunocytochemistry (ICC)
- Immunoprecipitation (IP)
Shipping:
4°C
Storage:
-20°C
Documents
Further Information
Applications:
IP - 10 ug/200 uL of cell extract from 5x106 cells FCM - 10 ug/mL (final concentration) ICC - 10 ug/mL
Background:
Granulysin is an antimicrobial
protein expressed on cytotoxic T cells, natural killer (NK)
cells and NKT cells. It has been shown that Granulysin
contributes to the defense mechanisms against variety of
mycobacterial infection and tumors. Granulysin has two
molecular forms, 15-kDa precursor and 9-kDa effector
form. There serum levels were significantly elevated
during the acute viral infections and correlated with the
NK cell and CTL activities in patients with sever
immunodeficiency, indicate that serum Granulysin could
be useful novel marker to evaluate the overall status of
host cell immunity.
Concentration:
1 mg/mL
Formulation:
100 ug IgG in 100 ul volume of PBS containing 50% glycerol, pH 7.2. No preservative iscontained.
Gene IDs:
Human: 10578
Immunogen Translated:
Human full-length expression plasmid Guranyuraishin
Reactivity:
This antibody immunoprecipitates
Granulysin.
Shelf Life:
3 years
Source:
This antibody was purified from hybridoma
(clone RC8) supernatant using protein A agarose. This
hybridoma was established by fusion of mouse myeloma
cell Sp2/0-Ag8 with Balb/c mouse splenocyte immunized
with pGrn-FLAG vector.
Target:
Granulysin
References
1) Ogawa, K., et al., Eur. J. Immunol.33, 1925-1933 (2003)
2) Gamen, S., et al., J. Immunol. 161, 1758-1764 (1998)
Clone RC8 is used in reference number 1).