Anti-Dlk (Pref-1) mAb

FCM - 5-10 ug/mL IHC - 10 ug/mL (paraffin), 1 ug/mL (frozen)

Delta like protein (Dlk), also known as Preadipocyte factor-1 (Pref-1) or zona glomerulosa-specific factor (ZOG), is an EGF-like transmembrane protein expressed preadipocytes but not in mature adipocytes. It is highly expressed in fetal liver, the adrenal gland, and placenta, as well as some neuroendocrine tumors and small cell lung carcinomas, where it plays a role in differentiation and proliferation. Dlk positively and negatively regulates adipocyte differentiation via at least four major variants (45-60 kDa) of Dlk generated by alternatively splicing. Constitutive expression of Dlk inhibits adipogenesis, but insulin or insulin like growth factor-1 (IGF-1) can circumvent this inhibition. Regulated processing of Dlk releases a 50 kDa soluble form that was previously characterized as Fetal Antigen-1, a protein involved in pancreatic island cell differentiation.

1 mg/mL

100 ug IgG in 100 ul volume of PBS containing 50% glycerol, pH 7.2. No preservative iscontained.

Human: 8788 Mouse: 13386

Pref-1-Fc protein

This antibody reacts with Dlk on Flow cytometry and Immunohistochemistry.

1 year

This antibody was purified from hybridoma (clone 24-11) supernatant using protein G agarose. This hybridoma was established by fusion of mouse myeloma cell with rat splenocyte immunized with Pref-1-Fc protein.

DLK/Pref-1