MBL

Anti-Aggrus (Podoplanin) (Human) mAb

Product Code:
 
MBL-D189-1
Product Group:
 
Primary Antibodies
Supplier:
 
MBL
Host Type:
 
Rat
Antibody Isotype:
 
IgG2a
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
YM-1
Regulatory Status:
 
RUO
Target Species:
 
Human
Applications:
  • Flow Cytometry
  • Immunohistochemistry (IHC)
  • Western Blot (WB)
Shipping:
 
4°C
Storage:
 
4°C
1 / 1
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MBL-D189-1100 ul£328.00
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Further Information

Applications:
WB - 1:500 (chemiluminescence detection system) FCM - 1:25 IHC - 0.0555555555555556
Background:
In addition to hemostasis and host defense, platelets are involved in the induction of inflammation, tissue repair, and tumor metastasis. Aggrus (T1α/Podoplanin) is a novel 36-45 kDa membrane sialoglycoprotein that induces platelet aggregation. Aggrus is highly expressed in various tumor cells and the platelet aggregation ability of Aggrus depends on specific oligosaccharide structures that may be related to the metastasis process in cancer cells. Aggrus has been identified as a diagnostic tumor marker for seminoma.
Formulation:
100 ul aliquot of concentrate antibody from the supernatant with preservative (0.09%sodium azide).*Azide may react with copper or lead in plumbing system to form explosive metal azides. Therefore, always flushdrains thoroughly with plenty of water when
Gene IDs:
Human: 10630 Mouse: 14726
Immunogen Translated:
Terminal peptide of human Aggrus N (38-51 a.a.)
Reactivity:
This antibody reacts with human Aggrus (36 kDa) on Western blotting.
Shelf Life:
3 years
Source:
This antibody was concentrated from hybridoma (clone YM-1) supernatant. This hybridoma was established by fusion of mouse myeloma cell P3-U1 with Sprague-Dawley rat splenocyte immunized with human Aggrus N-terminal peptide (38a.a.-51a.a.)
Target:
PDPN

Documents

References

1) Kaneko, M., et al., J. Biol. Chem. 279, 38838-38843 (2004) 2) Kato, Y., et al., Oncogene 23, 8552-8556 (2004) 3) Kato, Y., et al., J. Biol. Chem. 278, 51599-51605 (2003) Clone YM-1 is used in this reference 1).