MBL

Anti-CD52 (CAMPATH-1) (Mouse) mAb-PE

Product Code:
 
MBL-D204-5
Product Group:
 
Primary Antibodies
Supplier:
 
MBL
Host Type:
 
Rat
Antibody Isotype:
 
IgG2a
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
BTG-2G
Regulatory Status:
 
RUO
Target Species:
 
Mouse
Application:
 
Flow Cytometry
Shipping:
 
4°C
Storage:
 
4°C
 

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MBL-D204-550 Tests£317.00
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Further Information

Applications:
FCM - 20 uL
Background:
CAMPATH-1, also known as CD52, is a heavily glycosylated, GPI-anchored protein expressed at high levels on almost all thymocytes, lymphocytes, monocytes, and macrophages. CAMPATH-1 is an exceptionally good target for complement-mediated cell lysis and antibody-mediated cellular cytotoxicity. Humanized CAMPATH-1 antibodies have been used therapeutically to effectively deplete lymphocytes in allogeneic bone marrow transplants, hematologic malignancies, and autoimmune diseases. Clinical trials suggest CAMPATH-1 antibodies are especially promising in the treatment of leukemia, non-Hodgkin lymphomas, and rheumatoid arthritis. The apparent size of CAMPATH-1 by SDS-PAGE is 25-29 kDa; however, the actual molecule is much smaller, ~ 8-9 kDa as confirmed by total structure analysis and mass spectrometry.
Conjugate:
FITC
Formulation:
FORMULATION: 0.09% NaN3 ? 0.1% ProClin 150
Gene IDs:
Human: 1043 Mouse: 23833
Immunogen Translated:
Transgenic mouse spleen cell IL-2Ralpha
Reactivity:
This antibody reacts with mouse CD52 antigen on Flow cytometry.
Shelf Life:
1 year
Source:
This antibody was purified from hybridoma (clone BTG-2G) supernatant using protein G agarose. This hybridoma was established by fusion of mouse myeloma cell P3U1 with Wister rat splenocyte immunized with IL-2Rα-transgenic mouse splenocyte.
Target:
CAMPATH-1/CD52

Documents

References

1) Kubota, H., et al., J. Immunol. 145, 3924-3931 (1990) This antibody is used in this reference.