MBL

Anti-Desmoglein 3 (Mouse) mAb (No Azide)

Product Code:
 
MBL-D219-3
Product Group:
 
Primary Antibodies
Supplier:
 
MBL
Host Type:
 
Mouse
Antibody Isotype:
 
IgG1
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
AK23
Regulatory Status:
 
RUO
Target Species:
  • Human
  • Mouse
Applications:
  • Immunocytochemistry (ICC)
  • Immunohistochemistry (IHC)
  • Immunoprecipitation (IP)
Shipping:
 
4°C
Storage:
 
4°C
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CodeSizePrice
MBL-D219-3100 ug£296.00
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Further Information

Applications:
IP - Clone AK23 is used in reference 5) ICC - 0.1 ug/mL IHC - 0.1 ug/mL
Background:
Pemphigus vulgaris (PV) is a life -threatening autoimmune blistering disease of the skin and mucous membranes. In patients of PV, IgG autoantibodies against the cell surface of keratinocytes in stratified squamous epithelia play a major pathogenic role in loss of cell-cell adhesion. The autoimmune target of PV is desmoglein 3 (Dsg3), which is a member of the cadherin family of calcium-depending, transmembrane glycoprotein.
Concentration:
1 mg/mL
Formulation:
100 ug IgG in 100 ul volume of PBS, pH 7.2. No preservative is contained.
Gene IDs:
Human: 1830 Mouse: 13512
Immunogen Translated:
Hybridoma of spleen cells and mouse myeloma cells P3 mouse model of PV
Reactivity:
This antibody reacts with mouse and human Dsg3, and has the pathogenic activities in mice*. *This inducibility is reported in reference 5).
Shelf Life:
1 year
Source:
This antibody was purified from hybridoma (clone AK23) supernatant using protein A agarose. This hybridoma was established by fusion of splenocytes from PV model mouse and P3 mouse myeloma cells.
Target:
Desmoglein-3

Documents

References

1) Heupel, W. M., et al., J. Biol. Chem. 284, 8589-8595 (2009) 2) Chernyavsky, A. I., et al., J. Biol. Chem. 282, 13804-13812 (2007) 3) Calkins, C. C., et al., J. Biol. Chem. 281, 7623-7634 (2006) 4) Kottke, M. D., et al., J. Cell Sci. 119, 797-806 (2006) 5) Tsunoda, K., et al., J. Immunol. 170, 2170-2178 (2003) Clone AK23 is used in this reference.