Anti-CD274 (PD-L1) (Human) mAb-PE

FCM - 20 uL (ready for use)

Programmed death ligand 1 (PD-L1, also known as CD274/B7-H1), a member of B7 family was identified by searching for molecules that share homology with the immunogloblin V and C domains of B7-1 and B7-2 among the human cDNA expressed sequence tags in the National Center for Biotechnology Information database. PD-L1 is a ligand for programmed death 1 (PD-1) which belongs to the CD28/CTLA4 subfamily. Although in vitro study indicated that the cross-linking of PD-1 by PD-L1 leads to down-regulation of T-cell responses, some studies have shown that T cells stimulated with low levels of anti-CD3 and immobilized PD-L1-Ig were activated, proliferation and production of IFN-γ GM-CSF and IL-10 from the T cells were enhanced. The role of PD-L1 is now debatable.

50 tests in 1 mL volume of PBS containing 1% BSA and 0.09% NaN3. *Azide may react with copper or lead in plumbing system to form explosive metal azides. Therefore, always flush plenty of water when disposing materials containing azide into drain.

Human: 29126 Mouse: 60533

Recombinant human PD-L1 extracellular domain (CD274)

This antibody reacts with CD274 antigen on Flow cytometry.

1 year

This antibody was purified from hybridoma (clone 27A2) supernatant using protein A agarose. This hybridoma was established by fusion of mouse myeloma cell SP2/0 with Balb/c mouse splenocyte immunized with recombinant human PD-L1 extracellular domain.

CD274