MBL

Anti-Mesothelin (Mouse) mAb

Product Code:
 
MBL-D233-3
Product Group:
 
Primary Antibodies
Supplier:
 
MBL
Host Type:
 
Rat
Antibody Isotype:
 
IgG2a
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
B35
Regulatory Status:
 
RUO
Target Species:
 
Mouse
Application:
 
Flow Cytometry
Shipping:
 
4°C
Storage:
 
-20°C
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MBL-D233-3100 ug£323.00
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Further Information

Applications:
FCM - 10 ug/mL
Background:
Mesothelin (MSLN) is a GPI-linked cell surface glycoprotein expressed in the mesothelial lining of the body cavities and in mullerian duct epithelium related cancer cells (ovarian, pancreatic cancer, mesothelioma). Both human and mouse mesothelin bind to ovarian cancer antigen CA125/MUC16 with high affinity, mediating cell attachment in vitro, suggesting that mesothelin may facilitate ovarian cancer metastasis.
Concentration:
1 mg/mL
Formulation:
100 ug IgG in 100 ul volume of PBS containing 50% glycerol, pH 7.2. Contains nopreservatives.
Gene IDs:
Human: 10232 Mouse: 56047
Immunogen Translated:
Mouse cell-like cell line LO f Geo Blast Man
Reactivity:
This antibody reacts with mouse mesothelin on Flow cytometry.
Shelf Life:
1 year
Source:
This antibody was purified from nude mice ascites fluid using protein G agarose. This hybridoma (clone B35) was established by fusion of mouse myeloma cell P3X with Wister rat splenocyte immunized with the murine hemangioblast-like cell line LO.
Target:
Mesothelian

Documents

References

1) Gubbels, J. A., et al., Mol. Cancer 5, 50-64 (2006) 2) Ho, M., et al., Clin. Cancer Res. 11, 3814-3820(2005) 3) Rump, A., et al., J. Biol. Chem. 279, 9190-9198(2004) 4) Nakayama, K., et al., J. Biol. Chem. 274, 24766-24772 (1999) 5) Kojima, T., et al., J. Biol. Chem. 270, 21984-21990(1995) Clone B35 is used in reference number 3).