Anti-MORC3 (Human) mAb

WB - 1-5 ug/mL (chemiluminescence detection system) ICC - 5 ug/mL

MORC3 {mBACKGROUND: microrchidia (MORC) family CW-type zinc finger 3, KIAA0136, ZCWCC3 and NXP-2}, is a member of the MORC protein family characterized by the conserved domains consisting of a GHL (Gyrase B, Hsp90 and MutL)-ATPase domain at the N-terminus, a zinc finger type CW domain containing conserved four cysteines and two tryptophans, a nuclear localization signal (NLS) and coiled-coil domains at the C-terminus. There are four MORC family proteins (MORC1, MORC2, MORC3, and MORC4) in human and five (Morc1, Morc2a, Morc2b, Morc3, and Morc4) in mice. MORC1 is expressed specifically in male germ cells, whereas MORC2 and MORC3 in human are ubiquitously expressed. The autosomal recessive mutation of Morc1 in mice causes the arrest of spermatogenesis early in prophase I of meiosis. Takahashi et al. reported that MORC3 is involved in p53 activation and localization of conditionally localized p53 and constitutively localized Sp100 to promyelocytic leukemia (PML)-nuclear bodies (NBs) through its GHL-ATPase activity. MORC3 is localized in PML-nuclear bodies and entire nucleoplasm except for nucleoli.

1 mg/mL

100 ug IgG in 100 ul volume of PBS containing 50% glycerol, pH 7.2. No preservative is contained.

Human: 23515 Mouse: 338467

Recombinant human MORC3

1 year

This antibody was purified from hybridoma (clone 17A9) supernatant using protein A agarose. This hybridoma was established by fusion of mouse myeloma cell P3X63-Ag8.653 with Balb/c mouse splenocyte immunized with recombinant human MORC3.

MORC3