MBL

Anti-Mincle (Mouse) mAb-Biotin

Product Code:
 
MBL-D266-6
Product Group:
 
Primary Antibodies
Supplier:
 
MBL
Host Type:
 
Rat
Antibody Isotype:
 
IgG1 κ
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
1B6
Regulatory Status:
 
RUO
Target Species:
 
Mouse
Application:
 
Flow Cytometry
Shipping:
 
4°C
Storage:
 
-20°C
1 / 1
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MBL-D266-6100 ul£442.00
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  • Further Information
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Further Information

Applications:
FCM - 1:500
Background:
Macrophage-inducible C-type lectin (Mincle, also called as Clec4e and Clecsf9), a type ? transmembrane C-type lectin receptor, is expressed mainly in macrophages. Mincle is selectively associated with the Fc receptor common γ-chain which contains immunoreceptor tyrosine-based activation motif (ITAM) and activates macrophages to produce inflammatory cytokines and chemokines. Mincle expressing cells are activated by spliceosome associated protein 130 (SAP130) which is a component of small nuclear ribonucleoprotein released from dead cells.Recently, Mincle is reported to recognize Mycobacterium tuberculosis as well as pathogenic fungus Malassezia species. Mincle is demonstrated to be an essential receptor for a mycobacterial glycolipid, trehalose-6,6'-dimycolate (TDM). The cytokine/chemokine production of macrophages which Malassezia or M.tuberculosis induces in Mincle-/- mice is significantly impaired. Mincle is considered to play a crucial role in immune responses to pathogens.
Conjugate:
Biotin
Formulation:
PBS containing 1% BSA and 0.09% NaN3*Azide may react with copper or lead in plumbing system to form explosive metal azides. Therefore, always flush plenty of water when disposing materials containing azide into drain.
Immunogen Translated:
RBL-2H3 cells expressing full length mouse mincle
Reactivity:
This clone reacts with mouse Mincle (Clec4e) and crossreacts weakly with MCL (Clec4d).
Shelf Life:
1 year
Source:
Purified IgG from hybridoma supernatant
Target:
Mincle (Mouse)

Documents

References

1) Miyake, Y., et al., Immunity 38, 1050-1062 (2013) 2) Behler, F., et al., J. Immunol. 189, 3121-3129 (2012) 3) Yamasaki, S., et al., PNAS 106, 1897-1902 (2009) 4) Ishikawa, E., et al., J. Exp. Med. 206, 2879-2888 (2009) 5) Yamasaki, S., et al., Nat. Immunol. 9, 1179-1188 (2008)