MBL

Anti-CD42b (GPIbalpha) (Human) mAb

Product Code:
 
MBL-D274-3
Product Group:
 
Primary Antibodies
Supplier:
 
MBL
Host Type:
 
Mouse
Antibody Isotype:
 
IgG2a κ
Antibody Clonality:
 
Monoclonal
Antibody Clone:
 
TM60
Regulatory Status:
 
RUO
Target Species:
 
Human
Application:
 
Flow Cytometry
Shipping:
 
4°C
Storage:
 
-20°C
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MBL-D274-3100 ul£296.00
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  • Further Information
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Further Information

Applications:
FCM - 1 ug/mL (final concentration)
Background:
The platelet glycoprotein GPIb/IX/V complex functions as a receptor for the von Willebrand factor (vWf) and thrombin. The GPIb/IX/V complex comprises GPIbα, GPIbβ, GPIX (CD42a), and GPV (CD42d) in the ratio 2:2:2:1. GPIb (CD42b/c) is a heterodimer, composed of GPIbα (CD42b) and GPIbβ (CD42c), covalently associated by a disulfide bond. A monoclonal antibody, TM60, specifically recognizes human GPIbα (CD42b) and inhibits ristocetin-induced platelet aggregation and vWf-binding. It also inhibits thrombin-induced platelet aggregation. TM60 fails to bind to platelets from patients with Bernard-Soulier syndrome. The recognition epitope of TM60 is conformational; thus, it is impossible to use for western blot analysis.
Concentration:
1 mg/mL
Formulation:
100 ug IgG in 100 ul volume of PBS containing 50% glycerol, pH 7.2. No preservative iscontained.
Immunogen Translated:
Human platelet
Reactivity:
It is reported that this clone (TM60) recognizes human CD42b antigen in the reference number 4).
Shelf Life:
1 year
Source:
This antibody was purified from hybridoma (clone TM60) supernatant using protein A agarose. This hybridoma was established by fusion of mouse myeloma cell NS-1 with Balb/c mouse splenocyte immunized with human platelet.
Target:
CD42b

Documents

References

1) Cauwenberghs, N., et. al., Blood 98, 652-660 (2001) 2) Greco, N. J., et al., Biochemistry 35, 906-914 (1996) 3) Arai, M., et al., Br. J. Haematol. 87, 185-188 (1994) 4) Yamamoto, N., et al., Thromb. Res. 39, 751-759 (1985) Clone TM60 is used in the reference number 3) and 4).