Anti-CD62P (P-selectin) (Human) mAb
| Code | Size | Price |
|---|
| MBL-D280-3 | 100 ul | £296.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: IgG1 κ
Antibody Clonality: Monoclonal
Antibody Clone: 2T60
Regulatory Status: RUO
Target Species: Human
Application: Flow Cytometry
Shipping:
4°C
Storage:
-20°C
Documents
Further Information
Applications:
FCM - 1 ug/mL (final concentration)
Background:
CD62P, a platelet granule membrane
protein (GMP-140), is a member of the selectin family.
Since CD62P is expressed by the platelet surface on platelet
activation, it is also known as the platelet
activation-dependent granule-external membrane protein
(PADGEM). CD62P interacts with PSGL-1 (CD162),
which mediates the rolling of leukocytes on the surface of
activated endothelial cells, the first step in leukocyte
extravasation and migration towards inflammations. A
monoclonal antibody, 2T60, recognizes both human and
rabbit CD62P. In experimental cerebral thrombosis of
rabbits, 2T60 detects activated platelets adhering to the
damaged subendothelium and thrombi.
Concentration:
1 mg/mL
Formulation:
100 ug IgG in 100 ul volume of PBS containing 50% glycerol, pH 7.2. No preservative is contained.
Immunogen Translated:
Human platelet
Reactivity:
It is reported that this clone (2T60)
recognizes human CD62P antigen in the reference number
2).
Shelf Life:
1 year
Source:
This antibody was purified from hybridoma
(clone 2T60) supernatant using protein A agarose. This
hybridoma was established by fusion of mouse myeloma
cell NS-1 with Balb/c mouse splenocyte immunized with
human platelet.
Target:
CD62P
References
1) Burger, P. C., et al., Blood 101, 2661-2666 (2003)
2) Tanoue, K., et al., Platelets 4, 31-39 (1993)
3) McEver, R. P., et al., J. Clin. Invest. 84, 92-99 (1989)
4) Johnston, G. I., et al., Cell 56, 1033-1044 (1989)
Clone 2T60 is used in the reference number 2).