Anti-CD4 (Mouse) mAb-FITC
| Code | Size | Price |
|---|
| MBL-D341-4 | 1 mL (100 Tests) | £247.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rat
Antibody Isotype: IgG2b κ
Antibody Clonality: Monoclonal
Antibody Clone: GK1.5
Regulatory Status: RUO
Target Species: Mouse
Application: Flow Cytometry
Shipping:
4°C
Storage:
4°C
Documents
Further Information
Applications:
FCM - 10 uL (ready for use)
Background:
The CD4 antigen is a cell surface
glycoprotein that is expressed on subsets of thymocytes and
mature T lymphocytes, as well as on monocytes and
macrophages. CD4 is an accessory protein for MHC
class-II antigen/T-cell receptor interaction and plays an
important role in T-helper cell development and activation.
This monoclonal antibody GK1.5 reacts with a
non-polymorphic epitope on the mouse CD4 and a useful
tool for in vivo depletion of CD4+ T cells.
Concentration:
1 mg/mL
Conjugate:
FITC
Description:
The CD4 antigen is a cell surface glycoprotein that is expressed on subsets of thymocytes and mature T lymphocytes, as well as on monocytes and macrophages. CD4 is an accessory protein for MHC class-II antigen/T-cell receptor interaction and plays an important role in T-helper cell development and activation. This monoclonal antibody GK1.5 reacts with a non-polymorphic epitope on the mouse CD4 and a useful tool for in vivo depletion of CD4+ T cells.
Formulation:
100 tests in 1 mL volume of PBS containing 1% BSA and 0.09% NaN3.*Azide may react with copper or lead in plumbing system to formexplosive metal azides. Therefore, always flush plenty of waterwhen disposing materials containing azide into drain.
Gene IDs:
Mouse: 12504
Immunogen Translated:
Cloned cytotoxic T lymphocyte lines V4 and 243/2.5
Reactivity:
This antibody reacts with mouse CD4
antigen on Flow cytometry.
Shelf Life:
1 year
Source:
This antibody was purified from mouse ascites
fluid. This hybridoma (clone GK1.5) was established by
fusion of mouse myeloma cell SP2/0-Ag14 with Lewis rat
splenocyte immunized with the cloned cytotoxic T
lymphocyte lines V4 and 243/2.5.
Target:
CD4
References
1) Dialynas, DP., et al., Immunol Rev. 74: 29-56 (1983)
2) Dialynas, DP., et al., J. Immunol. 131: 2445-2451 (1983)
3) Rice, JC. and Bucy, RP., J. Immunol. 154: 6644-6654 (1995)
4) Buller, RM., et al., Nature 328: 77-79 (1987)
5) Ye, X., et al., Gene Ther. 7: 1761-1767 (2000)
6) Li, J., et al., Cancer Res. 63: 8384-8392 (2003)
7) Janssen, EM., et al., Nature 434: 88-93 (2005)
8) Moro, K., et al., Nature 463: 540-544 (2010)
9) Murooka, TT., et al., Nature 490: 283-287 (2012)
As clone GK1.5 is really famous all over the world, a lot
of researches have been reported. These references are a
part of such reports.