Anti-Pseudouridine mAb
| Code | Size | Price |
|---|
| MBL-D347-3 | 100 ul | £323.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: IgG2a κ
Antibody Clonality: Monoclonal
Antibody Clone: APU-6
Regulatory Status: RUO
Applications:
- Enzyme-Linked Immunosorbent Assay (ELISA)
- Immunocytochemistry (ICC)
- Immunohistochemistry (IHC)
Shipping:
4°C
Storage:
-20°C
Documents
Further Information
Applications:
ICC - 1 ug/mL
IHC - 1 ug/mL
Background:
Pseudouridine (ψ), the first modified RNA base to be identified, presents mostly in non-coding RNAs such as tRNA, rRNA, snRNA and snoRNA. It is also reported that pseudouridine has been found in mRNA in both yeast and human by sequencing analysis. Replacing uridine to pseudouridine enhances structural stability of RNA, and is expected to affect rRNA processing, mRNA translation and pre-mRNA splicing.
Formulation:
1 mg/mL in PBS/50% glycerol, pH 7.2
Immunogen Translated:
KLH-conjugated pseudouridine
Target:
Pseudouridine
References
Masuda M et al. An immunohistochemical analysis for cancer of the esophagus using monoclonal antibodies specific for modified nucleosides. Cancer 72, 3571-8 (1993) [IHC-P, ELISA] (PMID:8252470) Itoh K et al. Detection of elevated amounts of urinary pseudouridine in cancer patients by use of a monoclonal antibody. Clin Chim Acta 181, 305-15 (1989) [ELISA] (PMID:2758683) Itoh K et al. Diagnostic use of anti-modified nucleoside monoclonal antibody. Tohoku J Exp Med. 168, 329-31 (1992) (PMID:1306318)