Anti-MELK (Human) mAb
| Code | Size | Price |
|---|
| MBL-D373-3 | 100 ug/100 uL | £365.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: IgG1 κ
Antibody Clonality: Monoclonal
Antibody Clone: 11-28
Regulatory Status: RUO
Applications:
- Immunocytochemistry (ICC)
- Western Blot (WB)
Shipping:
4°C
Storage:
-20°C
Documents
Further Information
Alternative Names:
maternal embryonic leucine zipper kinase, hPK38, HPK38, pEg3 kinase
Applications:
WB - 1 ug/mL ICC - 1-5 ug/mL (Heat treatment is necessary for paraffin-embedded sections.)
Concentration:
100 ug/100 uL
Conjugate:
Unconjugated
Description:
MELK is a member of the AMPK serine/threonine kinase family. It is involved in mammalian embryonic development. Overexpression of MELK protein is also reported in various types of human cancer. MELK plays critical roles not only in cancer cell growth but also in formation or maintenance of cancer stem cells that have the ability to self-renew and differentiate. Emerging evidence indicates that cancer stem cells are resistant to chemotherapy and radiation therapy and are associated with cancer relapse. For these reasons, MELK is considered a promising drug target molecule for cancer treatment.
Formulation:
1 mg/mL in PBS/50% glycerol, pH 7.2
Immunogen Translated:
Recombinant protein, corresponding to amino acids 264-601 of human MELK
Target:
MELK