Anti-Txnip (VDUP1) (Human) mAb
| Code | Size | Price |
|---|
| MBL-K0204-3 | 100 ug | £345.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: IgG2b
Antibody Clonality: Monoclonal
Antibody Clone: JY1
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Applications:
- Immunoprecipitation (IP)
- Western Blot (WB)
Shipping:
4°C
Storage:
-20°C
Documents
Further Information
Applications:
WB - 10 ug/mL (chemiluminescence detection system) IP - 2 ug /200 uL of cell extract from 5x106 cells
Background:
Vitamin D3 up-regulated protein 1 (VDUP-1), also called Thioredoxin (TRX)-interacting protein, is an endogenous inhibitor of TRX. Redox-dependent regulation of VDUP-1 by mitogenic factors through Reactive oxygen species (ROS) and the specific binding of VDUP-1 to the redox-sensitive cysteine-sulfide center of TRX modulate intracellular levels of ROS and the mitogenic activity of TRX.
Concentration:
1 mg/mL
Formulation:
100 ug IgG in 100 ul PBS containing 50% glycerol, pH 7.2. Contains nopreservatives.
Gene IDs:
Human: 10628 Mouse: 56338 Rat: 117514
Immunogen Translated:
Recombinant human Txnip/VDUP1
Reactivity:
This antibody reacts with VDUP-1 (50
kDa) by Western blotting.
Shelf Life:
1 year
Source:
This antibody was purified from hybridoma
(clone JY1) supernatant using protein A agarose. This
hybridoma was established by fusion of mouse
plasmacytoma cell BIOS/2 with Balb/c mouse splenocyte
immunized with human recombinant VDUP-1/Txnip.
Target:
VDUP-1/Txnip
References
1) Yu, Y., et al., Free Radic Biol Med. 57, 92-104 (2013)
2) Nivet-Antoine,V., et al., Biochimie. 92, 1766-1771 (2010)[WB]
3) Yoshioka, J., et al., Circ. Res. 101, 1328-1338 (2007) [WB]
4) Jeon, J-H., et al., Cancer Res. 65, 4485-4489 (2005)
5) Yoshioka, J., et al., Circulation 109, 2581-2586 (2004)
6) Schulze, P. C., et al., J. Biol. Chem. 279, 30369-30374 (2004)