Anti-TLR2 (CD282) (Mouse) mAb

FCM - 10 ug/mL (final concentration)

Toll, a Drosophila receptor molecule with extracellular leucine-rich repeat (LRR), has a role in triggering innate defense against bacteria or fungi. Toll-like receptor 2 (TLR2) is a member of TLR family. Members of the TLR family are components of the mammalian anti-microbial response, signaling with a domain closely related to that of IL-1 receptors. TLR2 is expressed on the surface of cells and is responsible for distinguishing different pathogens. TLR2 has been identified as a receptor that is central to innate immune response to components of Gram-negative or Gram-positive bacteria. And a co-operative effect is observed between TLR2 and TLR6. For example, TLR2/TLR6 heterodimer recognizes lipopeptide derived from mycoplasma or zymosan. TLR2 and TLR4 are pattern recognition receptors and signaling molecules in response to bacterial lipoproteins and have been implicated in innate immunity and inflammation.

1 mg/mL

100 ug IgG in 100 ul PBS containing 50% glycerol, pH 7.2. Contains nopreservatives.

Human: 7097 Mouse: 24088

Recombinant mouse TLR2 (25-587 a.a.)

This antibody reacts with mouse TLR2 on flow cytometry.

1 year

This antibody was purified from culture supernatant using Protein A agarose. This hybridoma was established by fusion of mouse myeloma cell P3X with TLR2 knock out mouse splenocyte immunized with purified mouse TLR2.

TLR2