Anti-HLA-E (Human) mAb

FCM - 10 ug/mL (final concentration) IHC - It is reported that this monoclonal antibody can be used in immunohistochemistry on frozen section in the reference number 1).

HLA-E (human leucocyte antigen-E) is a conserved class I major histocompatibility molecule. It binds to the leader peptide derived from the polymorphic classical MHC molecules HLA-A, HLA-B and HLA-C. This peptide binding stabilizes the HLA-E protein and allows it to migrate to the cell surface. HLA-E then interacts with CD94/NKG2A receptors on natural killer cells. This interaction inhibits natural killer cell-mediated lysis of cells displaying HLA-E. In virally infected or tumor cells, down-regulation of HLA-A, HLA-B and HLA-C production prevents stabilization of HLA-E by the leader peptide. Under these circumstances, HLA-E is degraded before it reaches the cell surface and the cell is then vulnerable to lysis by natural killer cells.

1 mg/mL

100 ug IgG in 100 ul volume of PBS containing 50% glycerol, pH 7.2. No preservative is contained.

Antibody obtained by immunizing HLA-B27 transgenic mice to HLA-E protein

This antibody reacts with HLA-E on Flow cytometry.

1 year

This antibody was purified from hybridoma (clone 4D12) supernatant using protein A agarose. This antibody was established by immunization of HLA-B27 transgenic mice with HLA-E protein.

HLA-E