Anti-Msx2 (Human) mAb
| Code | Size | Price |
|---|
| MBL-M027-3 | 100 ug | £323.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: IgG2a κ
Antibody Clonality: Monoclonal
Antibody Clone: 2E12
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunohistochemistry (IHC)
- Western Blot (WB)
Shipping:
4°C
Storage:
4°C
Documents
Further Information
Applications:
WB - 1 ug/mL (chemiluminescence detection system) IHC - 10 ug/mL
Background:
Homeobox genes (HOX gene), which encode DNA binding proteins that recognize specific sequences and modulate transcriptional activity, are expressed during embryogenesis with positional specificity. HOX-8 (Msx2) mRNA is highly expressed in immature tumors, including a yolk sac tomor, seminoma and choriocarcinoma, and that its expression is higher in various tumors of epitherial origin than in the corresponding normal tissues. Msx2 gene expression is frequently activated in carcinoma-derived cell lines. The gene is inactive in NIH/3T3 cells but is transcriptionally activated after transformation by v-Ki-ras, suggesting that the Msx2 may play a positive role in cell transformation.
Concentration:
1 mg/mL
Formulation:
1.0 mg/mL in PBS/50% glycerol, pH 7.2
Gene IDs:
Human: 4488 Mouse: 17702
Immunogen Translated:
End Recombinant human Msx2 N (1-77a.a.)
Reactivity:
This antibody reacts with Msx2 on
Western blotting.
Shelf Life:
1 year
Source:
This antibody was purified from hybridoma
(clone 2E12) supernatant using protein A agarose. This
hybridoma was established by fusion of mouse myeloma
cell P3U1 with Balb/c mouse splenocyte immunized with
recombinant N-terminal amino acids of human Msx2 (1-77
aa.).
Target:
Msx2
References
1) Takahashi, C., et al., Oncogene 12, 2137-2146 (1996)
2) Suzuki, M., et al., Biochem. Biophys. Res. Commun. 194, 187-193 (1993)
3) Simeone, A., et al., Nature 320, 763-765 (1986)