Anti-Insulin B chain (Human) mAb

WB - 1-5 ug/mL IHC - 1 ug/mL

Insulin is one of the major regulatory hormones of carbohydrate, protein, and lipid metabolism throughout the body. Insulin enhances membrane transport of glucose, amino acids, and certain ions. It also decreases blood sugar levels and promotes glycogen storage, formation of triglycerides and synthesis of proteins and nucleic acids. Deficiency of insulin results in diabetes mellitus, one of the leading causes of morbidity and mortality. Insulin is a 5.8 kDa polypeptide composed of an A chain (21 amino acids) and a B chain (30 amino acids) connected by disulfide bonds. Immunocytochemical studies have localized insulin in the B cells of pancreatic islets of Langerhans. Antibodies to insulin are important as B?cell and tumor markers of the pancreas such as insulinomas or islet cell tumors.

1 mg/mL

100 ug IgG in 100 ul PBS containing 50% glycerol, pH 7.2. Contains no preservatives.

Human: 3480 Mouse: 16001

Recombinant human insulin

This antibody reacts with human recombinant Insulin B chain (3.5 kDa) on Western blotting.

1 year

This antibody was purified from hybridoma (clone 1C5A) supernatant using protein A agarose. This hybridoma was established by fusion of mouse myeloma cell P3U1 with Balb/c mouse splenocyte immunized with the recombinant human Insulin.

Insulin