Anti-CD11c (Mouse) mAb-Biotin
| Code | Size | Price |
|---|
| MBL-M100-6 | 500 ug | £280.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rat
Antibody Isotype: IgG2a
Antibody Clonality: Monoclonal
Antibody Clone: 223H7
Regulatory Status: RUO
Target Species: Mouse
Application: Flow Cytometry
Shipping:
4°C
Storage:
4°C
Documents
Further Information
Applications:
FCM - 2 ug/2.5 x 106 cells Other - 20 uL/2.5 x 107 cells (ready for use)
Background:
The CD11c (αX integrin; ~150 kDa) glycoprotein non-covalently associates with CD18 (β2 integrin; ~95 kDa) to form the heterodimeric complement receptor type 4 (CR4), which is involved in monocyte/granulocyte adhesion during inflammatory responses. The CD11c/CD18 receptor binds to CD54, iC3b and fibrinogen and plays a role in leukocyte adhesive interactions. CD11c/CD18 is also implicated in B cell proliferation and mediates B cell binding to fibrinogen. CD11c is commonly used as a marker for dendritic cells, but it is also expressed on macrophages, monocytes, granulocytes, NK cells, activated T and B lymphocytes and microglia.
Concentration:
0.5 ug/ml
Conjugate:
Biotin
Formulation:
500 ug IgG in 1 mL volume of PBS
containing 1% BSA and 0.09% NaN3.
Gene IDs:
Human: 3687 Mouse: 16411
Immunogen Translated:
DC derived from C57BL / 6 mouse
Reactivity:
This antibody reacts with CD11c on
Flow cytometry.
Shelf Life:
1 year
Source:
This antibody was purified from hybridoma
(clone 223H7) supernatant using protein G agarose. This
hybridoma was established by fusion of mouse myeloma
cell Sp2/0-Ag14 with Wister rat lymphocyte immunized
with murine DC from C57BL/6 mice.
Target:
CD11c
References
1) Kruger, T., et al., J. Am. Soc. Nephrol 15, 613-21
(2004)