Anti-Fas (CD95) (Human) mAb-FITC
| Code | Size | Price |
|---|
| MBL-MD-10-4 | 100 ul | £323.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: IgG1
Antibody Clonality: Monoclonal
Antibody Clone: UB2
Regulatory Status: RUO
Target Species: Human
Applications:
- Flow Cytometry
- Immunohistochemistry (IHC)
Shipping:
4°C
Storage:
4°C
Documents
Further Information
Applications:
FCM - 10 uL IHC - 10-20 ug/mL
Background:
It is now widely accepted that
apoptosis plays an important role in the selection of
immature thymocytes and Ag-primed peripheral T cells.
Fas antigen is a cell-surface protein that mediates
apoptosis. It is expressed in various tissues including the
thymus and has structural homology with a number of
cell-surface receptors, including tumor necrosis factor
receptor and nerve growth factor receptor.
Conjugate:
FITC
Formulation:
50 ug IgG in 100 uL volume of 1% BSA and 0.1% ProClin 150.
Gene IDs:
Human: 355 Mouse: 14102
Immunogen Translated:
Recombinant human Fas
Reactivity:
This antibody recognizes the human
Fas antigen specifically. Clone UB2 does not recognize the
mouse Fas antigen.
Shelf Life:
1 year
Source:
This antibody was purified from ascites fluid
(clone UB2) by ammonium sulfate precipitation and
affinity chromatography on protein A agarose. This
hybridoma was established by fusion of mouse myeloma
cell NS-1 with Balb/c mouse splenocyte immunized with
recombinant human Fas.
Target:
Fas
References
1) Vega, M. I., et al., J. Immunol. 175, 2174-2183 (2005)
2) Mezosi, E., et al., Mol. Endocrinol 19, 804-811(2005)
3) Hauptschein, R., et al., Cancer Res.65, 1887-1896 (2005)
4) Suhara, T., et al., Hypertension 43, 1208-1213 (2004)
5) Suhara, T., et al., Mol. Cell Biol. 22, 680-691 (2002)
6) Shinohara, H., et al., Cancer Res. 60, 1766-1772 (2000)
7) Sata, M., et al., Arterioscler. Thromb. Vasc. Biool.20, 309-316 (2000)
8) Hiromatsu, Y., et al., J. Clin. Endocrinol. Metab. 84, 2896-2902 (1999)
9) Kuwano, K., et al., Am. J. Respir. Cell Mol. Biol. 20, 53-60 (1999)
10) Dai, C. H., et al., Blood 91, 1235-1242 (1998)
11) Ando, K., et al., J. Immunol. 158, 5283-5291 (1997)
12) Boirivant, M., et al., J. Clin. Invest. 98, 2616-2622 (1996)
13) Hata, H., et al., Blood 86, 1939-1945 (1995)
14) Watanabe-Fukunaga, R., Nature 356, 314-317 (1992)
15) Ito, N., et al., Cell 66, 233-243 (1991)
16) Kobayashi, N., et al., PNAS. 87, 9620-9624 (1990)
17) Yonehara, S., et al., J. Exp.Med. 169, 1747-1756 (1989)
Clone UB2 is used in reference number 1) - 13).