Anti-Fas (CD95) (Human) mAb-Alexa Fluor 488
Code | Size | Price |
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MBL-MD-10-A48 | 100 uL | £323.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: IgG1
Antibody Clonality: Monoclonal
Antibody Clone: UB2
Regulatory Status: RUO
Target Species: Human
Applications:
- Flow Cytometry
- Immunohistochemistry (IHC)
Shipping:
4°C
Storage:
4°C
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Further Information
Applications:
FCM - 10 ug/mL (final concentration) IHC - 10-20 ug/mL
Background:
It is now widely accepted that apoptosis plays an important role in the selection of immature thymocytes and Ag-primed peripheral T cells. Fas antigen is a cell-surface protein that mediates apoptosis. It is expressed in various tissues including the thymus and has structural homology with a number of cell-surface receptors, including tumor necrosis factor receptor and nerve growth factor receptor.
Concentration:
1 mg/mL
Formulation:
100 ug IgG in 100 ul volume of PBS containing 1% BSA and 0.09% NaN3.
Gene IDs:
Human: 355 Mouse: 14102
Immunogen Translated:
Recombinant human Fas
Reactivity:
This antibody recognizes the human Fas antigen specifically. Clone UB2 does not recognize the mouse Fas antigen.
Shelf Life:
1 year
Source:
This antibody was purified from ascites fluid (clone UB2) by ammonium sulfate precipitation and affinity chromatography on protein A agarose. This hybridoma was established by fusion of mouse myeloma cell NS-1 with Balb/c mouse splenocyte immunized with recombinant human Fas.
Target:
Fas
References
1)
Boula, A., et al., Clin. Cancer Res. 12, 3099-3108 (2006)
2)
Vega, M. I., et al., J. Immunol. 175, 2174-2183 (2005)
3)
Mezosi, E., et al., Mol. Endocrinol 19, 804-811(2005)
4)
Hauptschein, R., et al., Cancer Res.65, 1887-1896 (2005)
5)
Suhara, T., et al., Hypertension 43, 1208-1213 (2004)
6)
Suhara, T., et al., Mol. Cell. Biol. 22, 680-691 (2002)
7)
Shinohara, H., et al., Cancer Res. 60, 1766-1772 (2000)
8)
Sata, M., et al., Arterioscler. Thromb. Vasc. Biool.20, 309-316 (2000)
9)
Hiromatsu, Y., et al., J. Clin. Endocrinol. Metab. 84, 2896-2902 (1999)
10)
Kuwano, K., et al., Am. J. Respir. Cell Mol. Biol. 20, 53-60 (1999)
11)
Dai, C. H., et al., Blood 91, 1235-1242 (1998)
12)
Ando, K., et al., J. Immunol. 158, 5283-5291 (1997)
13)
Boirivant, M., et al., J. Clin. Invest. 98, 2616-2622 (1996)
14)
Hata, H., et al., Blood 86, 1939-1945 (1995)
15)
Watanabe-Fukunaga, R., Nature 356, 314-317 (1992)
16)
Ito, N., et al., Cell. 66, 233-243 (1991)
17)
Kobayashi, N., et al., PNAS. 87, 9620-9624 (1990)
18)
Yonehara, S., et al., J. Exp.Med. 169, 1747-1756 (1989)
Clone UB2 is used in reference number 1) - 14).