Anti-Pax6 (Mouse) (Mouse) pAb

WB - 1:1000 (chemiluminescence detection system) IHC - Paraffin; 1:200 (Heat treatment is required) Frozen; 1:1000

Pax6 is a transcription factor that was first identified as a member of paired box (Pax) family protein and functions as the master gene controlling eye development. The mammalian Pax6 locus encodes at least three isoforms, the ?canonical? Pax6, Pax6(5a), and Pax6(δPD). Pax6 is also involved in various phenomena during development of the central nervous system, including patterning of the neural tube, migration of neurons, and formation of neural circuits. During development, Pax6 is expressed in neuroepithelial cells in the ventricular zone of the brain primordium and regulates proliferation and differentiation through the control of expression of different downstream factors such as FABP7 and Neurogenin2. On the other hand, Pax6 is expressed in neural stem/progenitor cells in the subgaranular zone of the hIPocampal dentate gyrus and the subventricular zone (SVZ) of the lateral ventricule throughout adult. Furthermore, intense expression of Pax6 is detected in SVZ-derived immature migrating neurons, cerebellar granule cells, precerebellar neurons and astrocytes in the cerebral cortex and spinal cord.

100 ul volume of PBS containing 50% glycerol, pH 7.2. No preservative is contained.

Human: 5080 Mouse: 18508 Rat: 25509

C-terminal peptide of mouse Pax6 (420-436 aa)

This antibody reacts with Pax6 on Western blotting and Immunohistochemistry. Additionally, it reacts with canonical Pax6 and Pax6(5a) in mouse embryonic cortex on Western blotting.

1 year

This antibody was purified from rabbit serum using affinity column. The rabbit was immunized with synthetic peptide corresponding to C-terminus of mouse Pax6 (420-436 aa).

Pax6