Anti-HRF (TCTP) (Human) pAb

WB - 1:1,000 (chemiluminescence detection system) IHC - 1:1,000 (Heat treatment required for paraffin)

The pathophysiological events of human allergic disease are characterized by infiltration of inflammatory cells and by the presence of mediators such as histamine. An IgE-dependent histamine releasing factor (HRF) produced by lymphocytes of atopic children and present in biological fluids of allergic patients has been identified and purified. HRF, also known as TCTP (Translationally Controlled Tumor Protein), Fortilin, Tumor protein-1 (Tpt-1), lens epithelial protein and p23, is as a 21 or 23 kDa protein produced in a variety of mouse and human cell lines, respectively1). HRF binds to a unique species of IgE on the surface of mast cells and basophils and thereby causes histamine release. The histamine released in late-phase reaction (LPR) of chronic allergic diseases such as asthma results from activation of basophils, eosinophils and lymphocytes infiltrate tissues during this response.

1 mg/mL

This antibody is supplied in 100 ul PBS (pH 7.2) containing 50% Glycerol. Contains no preservatives.

Human: 7178 Mouse: 22070 Rat: 116646

Full-length recombinant human HRF

This antibody reacts with HRF (23 kDa) by Western blotting.

1 year

This antibody is a protein-A sepharosepurified rabbit polyclonal antibody raised against a GST-HRF fusion protein corresponding to full length amino acids of human HRF (1-172 a.a.).

HRF/TCTP