Anti-IL-33 (Human) pAb

WB - 1:200 (chemiluminescence detection system) IHC - 1:500-1000 (Heat treatment required for paraffin)

nterleukin-1 (IL-1) family, such as IL-1α/β and IL-18, have important functions in host defense, immune regulation, and inflammation. IL-33, a member of the IL-1 family, that shows to induce T helper (Th) type 2 responses by signaling through the IL-1 receptor-related protein ST2 (IL-1R4), an orphan member of the IL-1 receptor family. Similarly to IL-1α/β and IL-18, IL-33 is synthesized as a 31 kDa precursor protein has been shown to be cleaved by caspase-1 in vitro. In vivo, IL-33 induces the expression of IL-4, IL-5, and IL-13 and leads to severe pathological changes in mucosal organs. IL-33 has been originally identified as NF-HEV, which is a nuclear factor preferentially expressed in high endothelial venules. IL-33 may function as both a proinflammatory cytokine and an intracellular nuclear factor involved in transcriptional regulation.

100 ul volume of PBS containing 50% glycerol, pH 7.2. No preservative is contained.

Human: 90865 Mouse: 77125

Full-length recombinant human IL-33 (270 a.a.)

This antibody reacts with IL-33 on Western blotting.

1 year

This antibody was purified from rabbit serum using affinity column. The rabbit was immunized with the recombinant full-length human IL-33 (270 aa).

IL-33/ST2 ????