Anti-5-hydroxymethylcytosine (5hmC) pAb
| Code | Size | Price |
|---|
| MBL-PM077 | 100 ul | £346.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Affinity Purified Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Applications:
- Immunoprecipitation (IP)
- Western Blot (WB)
Shipping:
4°C
Storage:
-20°C
Documents
Further Information
Applications:
WB - Dot blot: 1:5,000 IP - hMeDIP: 2 ul/sample
Background:
DNA methylation is one of many critical epigenetic modifications. In most cases, cytosine (C) in DNA sequence is converted to 5-methylcytosine (5mC) with addition of a methyl group by the enzymatic activity of DNA methyltransferase. DNA methylation plays a role in the regulation of gene expression. It has been reported that abnormal DNA methylation level is involved in many diseases.
5-hydroxymethylcytosine (5hmC), a newly identified epigenetic modification following 5mC, is generated from oxidation of 5mC by the enzymatic activity of TET family proteins. 5hmC may function as a regulator of gene expression as well as 5mC.
Formulation:
PBS/50% glycerol, pH 7.2
Immunogen Translated:
BSA-conjugated 5-hydroxymethylcytidine
Target:
5-hydroxymethylcytosine (5hmC)