Anti-NFIL3 (E4BP4) pAb
| Code | Size | Price |
|---|
| MBL-PM097 | 100 uL | £296.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Ig (aff.)
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species:
- Human
- Mouse
Application: Western Blot (WB)
Shipping:
-20°C
Storage:
-20°C
Documents
Further Information
Alternative Names:
IL3BP1, NFIL3A, NF-IL3A
Applications:
WB - 1:1,000 for chemiluminescence detection system
Background:
NFIL3, or E4BP4, is a transcription factor that controls sleep and circadian rhythms throughout the cranial nerve, endocrine, and metabolic systems.The circadian clock is a 24-hour endogenous oscillator, which cycles via transcriptional/translational feedback loops of clock genes and their products in individual cells. CLOCK and BMAL1 are positive factors in the loop, and their complex binds to E-box elements of PERs and CRYs. PER and CRY bind the CLOCK-BMAL1 complex, suppressing E-box-dependent transactivation and forming a molecular clock via this negative feedback mechanism.D-box and REV-ERB/ROR-binding elements also form a regulatory network of clock-controlled genes (CCGs). D-box-dependent transactivation is activated by DBP and repressed by NFIL3/E4BP4.NFIL3/E4BP4 expression also plays an important role in the immune system. NFIL3 polymorphisms are associated with inflammatory bowel disease (IBD).
Conjugate:
Unlabeled
Formulation:
1 mg/mL in PBS/50% glycerol, pH 7.2
Target:
NFIL3