Anti-ELAVL1 (HuR) mAb
| Code | Size | Price |
|---|
| MBL-RN007M | 200 ul | £404.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: IgG2a κ
Antibody Clonality: Monoclonal
Antibody Clone: C67-1
Regulatory Status: RUO
Target Species:
- Hamster
- Human
- Mouse
- Rat
Applications:
- Immunoprecipitation (IP)
- RIP
- Western Blot (WB)
Shipping:
4°C
Storage:
-20°C
Documents
Further Information
Applications:
WB - 1 μg/mL IP - 1.5 μg/50 μL of cell extract from 1.65 x 106 cells/sample RIP - 15 μg/500 μL cell extract from 1.65 x 107 cells
Background:
ELAVL1/HuR, like other ELAVL proteins, has a short N-terminal region followed by 2 RNA-binding motifs, a basic linker domain, and a third RNA-binding motif. The basic hinge region bears a novel nuclear shuttling sequence which is implicated in the nucleocytoplasmic HuR shuttling. Unlike its neuron-specific ELAV relatives (HuB, HuC and HuD), HuR itself is ubiquitously expressed. Structure-function analyses of HuR have shown that it binds to AU-rich mRNA sequences in the nucleus and may be involved in their nuclear export.
Formulation:
PBS containing 50% Glycerol (pH 7.2)
Gene IDs:
Human: 1994 Mouse: 15568 Rat: 363854
Target:
ELAVL1 (HuR)
References
1) Ma, W. J., et al., J. Biol. Chem. 271, 8144-8151 (1996)
2) Fan, X. C., and Steitz, J. A., PNAS 95, 15293-15298 (1998)
3) Fan, X. C., and Steitz, J. A., EMBO J, 17, 3448-3460 (1998)