Anti-SFPQ (PSF) mAb
| Code | Size | Price |
|---|
| MBL-RN014MW | 100 uL | £323.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: IgG2a κ
Antibody Clonality: Monoclonal
Regulatory Status: RUO
Target Species:
- Hamster
- Human
- Mouse
- Rat
Applications:
- Immunocytochemistry (ICC)
- Immunohistochemistry (IHC)
- Immunoprecipitation (IP)
- Western Blot (WB)
Shipping:
4°C
Storage:
-20°C
Documents
Further Information
Alternative Names:
POMP100, PPP1R140
Applications:
WB - 1 μg/mL IP - 2 µg/sample ICC - 0.5 μg/mL IHC - 1 μg/mL
Background:
Paraspeckle is one of newly identified subnuclear bodies consists of RNAs and RNA-binding proteins. SFPQ, also known as PSF, is a core component of paraspeckle and belongs to DBHS protein family. SFPQ forms heteromer by binding to other DHBS protein family, such as p54/NONO, and participates in mRNA splicing and transcriptional regulation in the nucleus. In Alzheimer's and Pick's diseases known as tauopathy, SFPQ is accumulated in cytoplasm in neurons and astrocytes. Altered localization of SFPQ together with tau mutation may be involved in pathogenesis of neurodegenerative diseases.
Conjugate:
Unconjugated
Formulation:
1 mg/mL in PBS/50% glycerol, pH 7.2
Gene IDs:
Human: 71514 Mouse: 252855
Immunogen Translated:
KLH-conjugated synthetic peptide, CAGYGRGREEYEGPNKKPRF (corresponding to amino acid residues 681-699 of mouse Sfpq)
Target:
SFPQ (PSF)
References
- Imamura K et al. Long noncoding RNA NEAT1-dependent SFPQ relocation from promoter region to paraspeckle mediates IL8 expression upon immune stimuli. Mol Cell 53, 393-406 (2014) (PMID:24507715) PMID:
- Hirose T et al. NEAT1 long noncoding RNA regulates transcription via protein sequestration within subnuclear bodies. Mol Biol Cell 25,169-83 (2014) (PMID:24173718) PMID:
- Elzbieta K et al. Distinct roles of DBHS family members in the circadian transcriptional feedback loop. Mol Cell Biol. 32, 4585-94 (2012) (PMID:22966205) PMID:
- Nakagawa S, Hirose T. Paraspeckle nuclear bodies--useful uselessness? Cell Mol Life Sci. 69, 3027–36 (2012) (PMID:22476590) PMID:
- Nakagawa S et al. Paraspeckles are subpopulation-specific nuclear bodies that are not essential in mice. J Cell Biol. 193, 31-9 (2011) (PMID:21444682) PMID:
- Kuwahara S et al. PSPC1, NONO, and SFPQ are expressed in mouse Sertoli cells and may function as coregulators of androgen receptor-mediated transcription. Biol Reprod. 75, 352-9 (2006) (PMID:16641145) PMID:
- Fox AH et al. Paraspeckles: a novel nuclear domain. Curr Biol. 12, 13-25 (2002) (PMID:11790299) PMID: