Anti-DICER1 (Human) pAb
| Code | Size | Price |
|---|
| MBL-RN030PW | 100 ul | £323.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Rabbit
Antibody Isotype: Affinity Purified Ig
Antibody Clonality: Polyclonal
Regulatory Status: RUO
Target Species: Human
Applications:
- Immunoprecipitation (IP)
- Western Blot (WB)
Shipping:
4°C
Storage:
-20°C
Documents
Further Information
Applications:
WB - 1 ug/mL for chemiluminescence detection system IP - 5 ug/500 uL of cell extract from
5 x 106 cells
Background:
Dicer1 is an endonuclease of the ribonuclease III (RNase III) family. It contains a DExH RNA helicase/ATPase domain, a Piwi/Argonaute/Zwille domain, a domain of unknown function, two RNase III domains, and a double-stranded RNA (dsRNA) binding domain. Dicer1 processes dsRNAs and pre-microRNAs into short RNA fragments of about 21?25 nucleotides in length. It is an initiating factor of the RNA interference pathway and plays a role in microRNA biogenesis and function. Dicer also mediates DNA hypermethylation and gene silencing in human colon cancer cell line.
Concentration:
1 mg/mL
Formulation:
100 ul volume of PBS containing 50% glycerol, pH 7.2. No preservative is contained.
Gene IDs:
Human: 23405 Mouse: 192119
Immunogen Translated:
Internal region synthetic peptide binding KLH, human DICER1
Reactivity:
This antibody reacts with human DICER1 on Western blotting and Immunoprecipitation.
Shelf Life:
1 year
Source:
This antibody was purified from rabbit serum by affinity column chromatography. The rabbit was immunized with KLH conjugated synthetic peptide, corresponding to internal region of human DICER1.
Target:
DICER1
References
1)
Ting, A. H., et al., Cancer Res. 68, 2570-2575 (2008)
2)
Maclae, I. J., et al., Science 311, 195-198 (2006)
3)
Zhang, H., et al., Cell 118, 57-68 (2004)