Anti-Osteopontin (SPP1) (Human) mAb
| Code | Size | Price |
|---|
| MBL-W052-3 | 100 ul | £345.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: IgG2a κ
Antibody Clonality: Monoclonal
Antibody Clone: 4A7D
Regulatory Status: RUO
Target Species: Human
Application: Flow Cytometry
Shipping:
4°C
Storage:
-20°C
Documents
Further Information
Applications:
FCM - 1-10 ug/mL
Background:
Osteopontin, also known as SPP1, is a secreted phosphoglycoprotein that belongs to the SIBLING family. Osteopontin binds to hydroxyapatite and is involved in anchoring of osteoclasts to the mineral matrix of bones. It also acts as a cytokine that mediates type I immune responses through enhancing the production of interferon-gamma and interleukin-12 while reducing production of interleukin-10. Osteopontin has been identified as a biomarker for ovarian cancer, prostate cancer, and non-small cell lung cancer.
Formulation:
1 mg/mL in PBS/50% glycerol, pH 7.2
Gene IDs:
Human: 6696
Immunogen Translated:
Human Osteopontin (SPP1) expressed Ba/F3 transfectants generated from SST-REX (signal sequence trap by retrovirus-mediated expression screening).
Reactivity:
This antibody reacts with human
Osteopontin (SPP1) on Flow cytometry.
Source:
This antibody was purified from hybridoma
culture supernatant by Protein A affinity column
chromatography.
Target:
Osteopontin (SPP1) (Human)
References
1) Kim, J. H., et al., JAMA 287, 1671-1679 (2002)
2) Ashkar, S., et al., Science 287, 860-864 (2000)
3) Kojima, T and Kitamura, T., Nat. Biotechnol. 17, 487-490 (1999)
4) Reinholt, F. P., et al., PNAS 87, 4473-4475 (1990)