Anti-CD358 (DR6) (Human) mAb
| Code | Size | Price |
|---|
| MBL-W072-3 | 100 ul | £345.00 |
Quantity:
Prices exclude any Taxes / VAT
Overview
Host Type: Mouse
Antibody Isotype: IgG2a κ
Antibody Clonality: Monoclonal
Antibody Clone: 3E2E4
Regulatory Status: RUO
Target Species: Human
Application: Flow Cytometry
Shipping:
4°C
Storage:
-20°C
Documents
Further Information
Applications:
FCM - 1-10 ug/mL
Background:
Death receptor 6 (DR6), also known as CD358 or TNFRSF21, is a member of the tumor necrosis factor receptor superfamily. DR6 contains a death domain and four TNFR-Cys repeats. It is highly expressed in the heart, brain, placenta, pancreas, lymph nodes, thymus, and prostate. DR6 activates nuclear factor kappa-B and mitogen-activated protein kinase 8 and induces cell apoptosis. Overexpression of DR6 has been observed in several cancers including ovarian cancer and sarcoma.
Formulation:
1 mg/mL in PBS/50% glycerol, pH 7.2
Gene IDs:
Human: 27242
Immunogen Translated:
Human CD358 (DR6) expressed Ba/F3 transfectants generated from SST-REX (signal sequence trap by retrovirus-mediated expression screening).
Reactivity:
This antibody reacts with human CD358
(DR6) on Flow cytometry.
Source:
This antibody was purified from hybridoma
culture supernatant by Protein A affinity column
chromatography.
Target:
CD358 (DR6) (Human)
References
1) Kojima, T. and Kitamura,T., Nat. Biotechnol. 17, 487-490 (1999)
2) Pan, G., et al., FEBS Lett. 431, 351-356 (1998)